Penicillamine Treatment in Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
Penicillamine in the treatment of rheumatoid arthritis.
Between 1973 and 1979, 203 patients with classical or definite rheumatoid arthritis were treated with chloroquine phosphate, gold, or penicillamine. Of 132 receiving penicillamine, 76 received it as the sole treatment. Forty of 50 withdrawals from penicillamine were side effect-related, although 4 of these 50 subsequently resumed therapy. Nineteen showed no response to penicillamine. Eight-six ...
متن کاملD-penicillamine in rheumatoid arthritis.
D-penicillamine (D-pen) has gained wide-spread use as a potent suppressor of disease activity in rheumatoid arthritis (RA) and juvenile chronic arthritis (JCA). The drug has been established for antirheumatotd therapy on the basis o f a considerable number o f comparative clinical studies o f D-pen treatment versus placebo or other disease modifying antirheumatic drugs (DMARDs). Despite the pos...
متن کامل[D-penicillamine in rheumatoid arthritis].
In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis.
متن کامل[D-penicillamine in the treatment of rheumatoid arthritis].
Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patie...
متن کاملDiffuse alveolitis as complication of penicillamine treatment for rheumatoid arthritis.
Penicillamine is as effective as gold' when used as an antirheumatic drug.2 Side effects may occur, however, the best recognised being marrow suppression, the nephrotic syndrome, abnormalities of taste, rashes, and gastrointestinal disturbances. All are usually reversible on stopping treatment. Nevertheless, deaths have occurred, and recently three fatal cases of Goodpasture's syndrome were rep...
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ژورنال
عنوان ژورنال: Acta Medica Scandinavica
سال: 2009
ISSN: 0001-6101
DOI: 10.1111/j.0954-6820.1980.tb09683.x